Research and Achievements

Fiscal Year2025

Achievements for Fiscal Year2025

  1. Sasa N, Kojima S, Koide R, Hasegawa T, Namkoong H, Hirota T, Watanabe R, Nakamura Y, Oguro-Igashira E, Ogawa K, Yata T, Sonehara K, Yamamoto K, Kishikawa T, Sakaue S, Edahiro R, Shirai Y, Maeda Y, Nii T, Chubachi S, Tanaka H, Yabukami H, Suzuki A, Nakajima K, Arase N, Okamoto T, Nishikawa R, Namba S, Naito T, Miyagawa I, Tanaka H, Ueno M, Ishitsuka Y, Furuta J, Kunimoto K, Kajihara I, Fukushima S, Miyachi H, Matsue H, Kamata M, Momose M, Bito T, Nagai H, Ikeda T, Horikawa T, Adachi A, Matsubara T, Ikumi K, Nishida E, Nakagawa I, Yagita-Sakamaki M, Yoshimura M, Ohshima S, Kinoshita M, Ito S, Arai T, Hirose M, Tanino Y, Nikaido T, Ichiwata T, Ohkouchi S, Hirano T, Takada T, Tazawa R, Morimoto K, Takaki M, Konno S, Suzuki M, Tomii K, Nakagawa A, Handa T, Tanizawa K, Ishii H, Ishida M, Kato T, Takeda N, Yokomura K, Matsui T, Uchida A,Inoue H, Imaizumi K, Goto Y, Kida H, Fujisawa T, Suda T, Yamada T, Satake Y, Ibata H, Saigusa M,Shirai T, Hizawa N, Nakata K; Japan COVID-19 Task Force; Imafuku S, Tada Y, Asano Y, Sato S, Nishigori C, Jinnin M, Ihn H, Asahina A, Saeki H, Kawamura T, Shimada S, Katayama I, Poisner HM, Mack TM, Bick AG, Higasa K, Okuno T, Mochizuki H, Ishii M, Koike R, Kimura A,  Noguchi E, Sano S, Inohara H, Fujimoto M, Inoue Y, Yamaguchi E, Ogawa S, Kanai T, Morita A, Matsuda F,Tamari M, Kumanogoh A, Tanaka Y, Ohmura K, Fukunaga K, Imoto S, Miyano S, Parrish NF, Okada Y. Blood DNA virome associates with autoimmune diseases and COVID-19. Nat Genet.2025 Jan;57(1):65-79. doi: 10.1038/s41588-024-02022-z. Epub 2025 Jan 3. 
  2. Shimada T, Maetani T, Chubachi S, Tanabe N, Asakura T, Namkoong H, Tanaka H,　Azekawa S,  Otake S, Nakagawara K, Fukushima T, Watase M, Shiraishi Y, Terai H, Sasaki M, Ueda S, Kato Y,  Harada N, Suzuki S, Yoshida S, Tateno H, Shimizu K, Sato S, Yamada Y, Jinzaki M, Hirai T,  Okada Y, Koike R, Ishii M, Kimura A, Imoto S, Miyano S, Ogawa S, Kanai T, Fukunaga K. Erector Spinae Muscle to Epicardial Visceral Fat Ratio on Chest CT Predicts the Severity of Coronavirus　Disease 2019. J Cachexia Sarcopenia Muscle. 2025 Feb;16(1):e13721. doi: 10.1002/jcsm.13721.
  3. Watase M, Shiraishi Y, Chubachi S, Tanabe N, Maetani T, Asakura T, Namkoong H, Tanaka H, Shimada T, Azekawa S, Otake S, Fukushima T, Nakagawara K, Masaki K, Terai H, Mochimaru T, Sasaki M, Ueda S, Kato Y, Harada N, Suzuki S, Yoshida S, Tateno H, Yamada Y, Jinzaki M, Okada Y, Koike R, Ishii M, Kimura A, Imoto S, Miyano S, Ogawa S, Kanai T, Fukunaga K. Coronary Artery Calcification on Chest Computed Tomography as a Predictor of Cardiovascular Adverse Events in Patients With COVID-19　- A Multicenter Retrospective Study in Japan. Circ J.2025 Feb 25;89(3):373-381. doi: 10.1253/circj.CJ-24-0661. Epub 2025 Jan 18. 
  4. Watase M, Masaki K, Chubachi S, Namkoong H, Tanaka H, Lee H, Fukushima T, Otake S, Nakagawara K, Kusumoto T, Asakura T, Kamata H, Ishii M, Hasegawa N,Oyamada Y, Harada N, Ueda T, Ueda S, Ishiguro T, Arimura K, Saito F, Yoshiyama T, Nakano Y, Mutoh Y, Suzuki Y, Edahiro R, Sano H, Sato Y, Okada Y, Koike R, Kitagawa Y,Tokunaga K, Kimura A, Imoto S, Miyano S, Ogawa S,  Kanai T, Fukunaga K; Japan COVID-19 Task Force. Corrigendum to 'Impact of accumulative smoking exposure and chronic obstructive pulmonary disease on COVID-19 outcomes: report based on findings from the Japan COVID-19 task force' [IJID 128 (2023) 121-127]. Int J Infect Dis. 2025 Feb;151:107322. doi: 10.1016/j.ijid.2024.107322. Epub 2024 Dec 10. Erratum for: Int J Infect Dis. 2023 Mar;128:121-127. doi: 10.1016/j.ijid.2022.12.019.
  5. Ozawa T, Chubachi S, Namkoong H, Nemoto S, Ikegami R, Asakura T,T anaka H, Lee H, Fukushima T,  Azekawa S, Otake S, Nakagawara K, Watase M, Masaki K, Kamata H, Harada N, Ueda T, Ueda S,  Ishiguro T, Arimura K, Saito F, Yoshiyama T, Nakano Y, Muto Y, Suzuki Y, Edahiro R, Murakami K, Sato Y, Okada Y, Koike R, Ishii M, Hasegawa N, Kitagawa Y, Tokunaga K, Kimura A, Miyano S, Ogawa S, Kanai T, Fukunaga K, Imoto S. Predicting coronavirus disease 2019 severity using  explainable artificial intelligence techniques. Sci Rep. 2025 Mar 19;15(1):9459. doi: 10.1038/s41598-025-85733-5.
  6. Sonehara K, Uwamino Y, Saiki R, Takeshita M,Namba S, Uno S,Nakanishi T, Nishimura T, Naito T, Sato G, Kanai M, Liu A, Uchida S, Kurafuji T, Tanabe A, Arai T, Ohno A, Shibata A, Tanaka S,  Wakui M, Kashimura S, Tomi C, Hara A, Yoshikawa S, Gotanda K, Misawa K, Tanaka H, Azekawa S, Wang QS, Edahiro R, Shirai Y, Yamamoto K, Nagao G, Suzuki T, Kiyoshi M, Ishii-Watabe A, Higashiue S, Kobayashi S, Yamaguchi H, Okazaki Y, Matsumoto N, Masumoto A, Koga H, Kanai A; Japan COVID-19 Task Force; Biobank Japan Project; Oda Y, Suzuki Y, Matsuda K, Kitagawa Y, Koike R,Kimura A,Kumanogoh A,Yoshimura A, Imoto S, Miyano S, Kanai T, Fukunaga K, Hasegawa N, Murata M, Matsushita H, Ogawa S, Okada Y, Namkoong H. Germline variants and mosaic chromosomal alterations affect COVID-19 vaccine immunogenicity. Cell Genom.2025 Mar 12;5(3):100783. doi: 10.1016/j.xgen.2025.100783. Epub 2025 Mar 4.

  7. Yata T, Sato G, Ogawa K, Naito T, Sonehara K, Saiki R, Edahiro R, Namba S, Watanabe M, Shirai Y, Yamamoto K, NamKoong H, Nakanishi T, Yamamoto Y, Hosokawa A, Yamamoto M; Japan MS/NMOSD biobank; BioBank Japan Project; Japan COVID-19 Task Force; Oguro-Igashira E, Nii T, Maeda Y, Nakajima K, Nishikawa R, Tanaka H, Nakayamada S, Matsuda K, Nishigori C, Sano S, Kinoshita M, Koike R, Kimura A, Imoto S, Miyano S, Fukunaga K, Mihara M, Shimizu Y, Kawachi I, Miyamoto K, Tanaka Y, Kumanogoh A, Niino M, Nakatsuji Y, Ogawa S, Matsushita T, Kira JI, Mochizuki H, Isobe N, Okuno T, Okada Y. Contribution of germline and somatic mutations to risk of neuromyelitis optica spectrum disorder. Cell Genom. 2025 Mar 12;5(3):100776. doi: 10.1016/j.xgen.2025.100776. Epub 2025 Feb 21. 

  8. Park H, Wang QS, Hasegawa T, Namkoong H, Tanaka H, Koike R, Kitagawa Y, Kimura A, Imoto S, Kanai T, Fukunaga K, Ogawa S, Okada Y, Miyano S. Unraveling the COVID-19 Severity Hubs and Interplays in Inflammatory-Related RNA-Protein Networks. Int J Mol Sci. 2025 May 6;26(9):4412. doi: 10.3390/ijms26094412.
  9. Takahashi Y, Wang QS, Hasegawa T, Namkoong H,Inoue F, Fukunaga K,Imoto S,Miyano S, Okada Y; Japan COVID-19 Task Force. JOB: Japan Omics Browser provides integrative visualization of multi-omics data. BMC Genomics. 2025 May 7;26(1):451. doi: 10.1186/s12864-025-11639-1. 
  10. Uwamino Y, Yokoyama T, Sato Y, Tanaka S, Kamoshita Y, Shibata A, Kurafuji T, Tanabe A, Arai T, Ohno A, Namkoong H, Nishimura T, Wakui M, Murata M, Hasegawa N, Matsushita H.　 Breakthrough Infection After a Primary Series of COVID-19 Vaccination Induces Stronger Humoral Immunity and　Equivalent Cellular Immunity to the Spike Protein Compared with Booster Shots.  Vaccines (Basel). 2025 Jul 13;13(7):751. oi:10.3390/vaccines13070751. 
  11. Yagi K, Kondo M, Terai H, Asakura T, Kimura R, Takemura R, Tanaka H, Ohgino K, Masaki K,  Namkoong H, Chubachi S, Miyata J, Kawada I, Kaido T,Mashimo S, Kobayashi K, Hirano T, Lee H,  Sugihara K, Omori N, Watase M, Mochimaru T, Satomi R, Makino Y, Inoue T, Sayama K, Oyamada Y,  Ishii M, Sato Y, Fukunaga K. Impact of long COVID on the health-related quality of life of Japanese patients: A prospective nationwide cohort study. Respir Investig.  2025 Jul;63(4):610-616. doi: 10.1016/j.resinv.2025.05.001. Epub 2025 May 10.
  12. Edahiro R, Sato G, Naito T, Shirai Y, Saiki R, Sonehara K, Tomofuji Y, Yamamoto K, Namba S,  Sasa N, Nagao G, Wang QS, Takahashi Y, Hasegawa T, Kishikawa T, Suzuki K, Liu YC, Motooka D, Takuwa A, Tanaka H, Azekawa S; Japan COVID-19 Task Force; Namkoong H, Koike R, Kimura A,  Imoto S,Miyano S,Kanai T,Fukunaga K,Uemura M, Morita T, Kato Y, Hirata H, Takeda Y,DokiY,  Eguchi H, Okuzaki D, Sakakibara S, Ogawa S, Kumanogoh A, Okada Y. Deciphering state-dependent  immune features from multi-layer omics data at single-cell resolution. Nat Genet. 2025 Aug;57(8):1905-1921. doi: 10.1038/s41588-025-02266-3. Epub 2025 Jul 28.

  13. Tanaka H, Kamata H, Ishii M, Asakura T, Namkoong H, Nakagawara K, Morita A, Kusumoto T,  Azekawa S, Kaji M, Nagao G, Fukunaga N, Nishimura T, Asakura K, Hasegawa N, Fukunaga K. Sectm1a Depletion Promotes Neutrophil Recruitment during Pneumococcal Pneumonia. Am J Respir Cell Mol Biol. 2025 Jul;73(1):60-72. doi:10.1165/rcmb.2024-0276OC.

  14. Kusumoto T,Yotsukura M,Asakura T, Namkoong H, Ogawa T, Hegab AE,Nakatake Y, Oda M, Saito F,  Kamata H, Hamamoto J, Okamori S, Seki M, Suzuki Y, Hasegawa N, Asamura H, Watanabe H, Ko MSH,  Ieda M, Fukunaga K, Ishii M. Induced lung epithelial-like cells derived by direct reprogramming rescue influenza virus-induced lung injury in mice. Biochem Biophys Res Commun.2025 Sep 8;778:152384. doi: 10.1016/j.bbrc.2025.152384. Epub 2025 Jul 17.
  15. Bhak Y, Raptis V, He Y, Nakanishi T, Macdonald-Dunlop E, Sagiya Y, Morisaki T, Matsuda K; BioBank Japan Project; Japan COVID-19 Task Force; Kanai A, Suzuki Y, Oda Y, Kamatani Y,  Namkoong H, Saiki R, Kimura A, Koike R, Ogawa S, Miyano S, Imoto S, Kanai T, Fukunaga K, Okada Y, Mälarstig A, Tenesa A. Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases. Sci Rep. 2025 Aug 28;15(1):31721. doi: 10.1038/s41598-025-10031-z.

  16. Nakagawa T, Fujita K, Miki M, Ito A, Namkoong H, Asakura T, Morimoto K, Hasegawa N, Kita T,  Watanabe A, Tsuyuguchi K, Kawashima M, Shiozawa A, Watanabe S, Sato A, Kato T, Kimizuka Y, Harada H, Fujita K, Saito AM, Hashimoto H, Inoue Y, Ogawa K. Intermittent versus Daily Therapy   for Noncavitary Mycobacterium avium Complex Pulmonary Disease: An Open-Label Randomized Trial.  Ann Am Thorac Soc. 2025 Aug;22(8):1183-1192. doi: 10.1513/AnnalsATS.202406-626OC.

  17. Rowntree LC, Allen LF, Hagen RR, McQuilten HA, Quadeer AA, Chaurasia P,Kaewpreedee P,Lee KWK,Cohen CA,Petersen J, Littler DR, Habel JR, Zhang W, Cheng SMS, Chan KKP, Kwok JSY, Leung KSM, Wu JT,Lee CK,Davies J, Pannaraj PS, Kaity Allen E, Thomas PG, Tosif S, Crawford NW, Lappas M, Thevarajan I, Lewin SR, Kent SJ, Juno JA, Bond KA, Williamson DA, Holmes NE, Smibert OC, Gordon CL, Trubiano JA, Kotsimbos TC, Cheng AC, Efstathiou C, Turtle L, Thwaites RS, Brightling CE; PHOSP-COVID Collaborative Group; Rossjohn J, McKay MR, Tian J, Liu WJ, Gao GF, Xu J, Sonehara K, Ishii KJ,Namkoong H, Okada Y, Peiris M, Hui DSC, Poon LLM, Doherty PC, Nguyen THO, Valkenburg SA, Kedzierska K. HLA-B*15:01-positive severe COVID-19 patients lack CD8+ T cell pools with highly expanded public clonotypes. Proc Natl Acad Sci U S A. 2025 Sep9;122(36):e2503145122. doi: 10.1073/pnas.2503145122. Epub 2025 Sep 2.

  18. Saito A, Otake S, Ohgino K, Bun S, Mimura Y, Ito D, Miyazaki N, Nagashima K, Terai H, Chubachi S, Masaki K, Miyata J, Kawada I, Namkoong H, Hashiguchi M, Kagyo J, Shiomi T, Masuzawa K,Asakura T, Nakayama S, Suzuki Y, Minematsu N, Manabe T, Fukui T, Funatsu Y, Koh H, Fukunaga K. Anxiety, depression, and fear after coronavirus disease 2019 infection and their association with long coronavirus disease symptoms. Front Psychiatry. 2025 Sep 10;16:1672447. doi: 10.3389/fpsyt.2025.1672447.

  19. Park K, Kim H, Huh HJ, Namkoong H, Hasegawa N, Nishimura T, Asakura T, Morimoto K, Kurashima A, Omae Y, Kawai Y, Tokunaga K, Berghout J, Fennelly KP, Holland SM, Cho J, Yim JJ, Won S, Jhun BW, Won HH. Novel Genetic Loci for Nontuberculous Mycobacterial Pulmonary Disease and Potential Protective Effect of Body Mass Index. Am J Respir Crit Care Med. 2025 Sep 12.doi: 10.1164/rccm.202406-1253OC. Epub ahead of print.
  20. Aoki W, Uwamino Y, Niida N, Kubota H, Kamoshita Y, Inose R, Nagata M, Ishihara O, Uno S, Yoshifuji A, Namkoong H, Hasegawa N, Matsushita H. Cefiderocol susceptibility of 　Stenotrophomonas maltophilia species complex and carbapenem-resistant Pseudomonas aeruginosa isolates from blood cultures at a university hospital in Tokyo, Japan. J Glob Antimicrob Resist. 2025 Sep;44:251-255. doi: 10.1016/j.jgar.2025.07.004. Epub 2025 Jul 7.

  21. Morita A, Ishii M, Asakura T, Yotsukura M, Hegab AE, Kusumoto T, Namkoong H, Ogawa T,   Nakatake Y, Oda M, Saito F,Kamata H, Hamamoto J, Okamori S, Ebisudani T, Yasuda H, Sugimoto S,   Kuze Y, Seki M, Suzuki Y, Hasegawa N, Asamura H, Watanabe H, Ko M, Sato T, Ieda M, Fukunaga K.  Direct reprogramming of mouse fibroblasts into self-renewable alveolar epithelial-like cells.  NPJ Regen Med. 2025 Jun 23;10(1):30. doi: 10.1038/s41536-025-00411-4. 

  22. Sonehara K, Uwamino Y, Saiki R, Takeshita M, Namba S, Uno S, Nakanishi T, Nishimura T, Naito T, Sato G, Kanai M, Liu A, Uchida S, Kurafuji T, Tanabe A, Arai T, Ohno A, Shibata A, Tanaka S, Wakui M, Kashimura S, Tomi C, Hara A, Yoshikawa S, Gotanda K, Misawa K, Tanaka H, Azekawa S, Wang QS, Edahiro R, Shirai Y, Yamamoto K, Nagao G, Suzuki T, Kiyoshi M, Ishii-Watabe A, Higashiue S, Kobayashi S, Yamaguchi H, Okazaki Y, Matsumoto N, Masumoto A, Koga H, Kanai A; Japan COVID-19 Task Force; Biobank Japan Project; Oda Y, Suzuki Y, Matsuda K, Kitagawa Y, Koike R, Kimura A, Kumanogoh A, Yoshimura A, Imoto S, Miyano S, Kanai T, Fukunaga K, Hasegawa N, Murata M, Matsushita H, Ogawa S, Okada Y, Namkoong H. Germline variants and mosaic chromosomal alterations affect COVID-19 vaccine immunogenicity. Cell Genom. 2025 Mar 12;5(3):100783.
  23. Tomisaki E, Haruta J, Horiguchi T, Arahata T, Fukui R, Uno S, Ando T, Yoshino T, Ishikawa S, Suzuki S, Yamaura K, Monkawa T. A Simulated Interprofessional Team Conference Using Cross-Training for Junior Healthcare Students in Interprofessional Education: a Qualitative Content Analysis. Adv Med Educ Pract. 2025 Apr 11;16:583-594.
  24. Ethridge AD, Yagi K*, Martínez LA, Rasky AJ, Morris SB, Falkowski NR, Huffnagle GB, Lukacs NW. RSV infection in neonatal mice and gastrointestinal microbiome alteration contribute to allergic predisposition. Mucosal Immunol 2025 Apr 23:S1933-0219(25)00045-5. Epub ahead of print.
  25. Yagi K, Kondo M, Terai H, Asakura T, Kimura R, Takemura R, Tanaka H, Ohgino K, Masaki K, Namkoong H, Chubachi S, Miyata J, Kawada I, Kaido T, Mashimo S, Kobayashi K, Hirano T, Lee H, Sugihara K, Omori N, Watase M, Mochimaru T, Satomi R, Makino Y, Inoue T, Sayama K, Oyamada Y, Ishii M, Sato Y, Fukunaga K. Impact of long COVID on the health-related quality of life of Japanese patients: A prospective nationwide cohort study. Respir Investig 2025; 63: 610-616.

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