Research and Achievements

Fiscal Year2018

Achievements for Fiscal Year 2018

    1. Namkoong H, Ishii M, Fujii H, Yagi K, Asami T, Asakura T, Suzuki S, Hegab AE, Kamata H, Tasaka S, Atarashi K, Nakamoto N, Iwata S, Honda K, Kanai T, Hasegawa N, Koyasu S, Betsuyaku T. Clarithromycin expands CD11b+Gr-1+ cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia. PLoS Pathog. 2018 Apr 5. 14(4): e1006955.
    2. Kubota H, Uwamino Y, Matsui M, Sekizuka T, Suzuki Y, Okuno R, Uchitani Y, Ariyoshi T, Aoki W, Suzuki S, Kuroda M, Shinkai T, Yokoyama K, Sadamasu K, Funakoshi T, Murata M, Hasegawa N, Iwata S. FRI-4 carbapenemase-producing Enterobacter cloacae complex isolated in Tokyo, Japan. J Antimicrob Chemother. 2018 Nov 1. 73(11) 2969-2972.
    3. Imai K, Tarumoto N, Amo K, Takahashi M, Sakamoto N, Kosaka A, Kato Y, Mikita K, Sakai J, Murakami T, Suzuki Y, Maesaki S, Maeda T. Non-invasive diagnosis of cutaneous leishmaniasis by the direct boil loop-mediated isothermal amplification method and MinION™ nanopore sequencing. Parasitol Int. 2018 Feb;67(1):34-37.
    4. Aoki K, Harada S, Yahara K, Ishii Y, Motooka D, Nakamura S, Akeda Y, Iida T, Tomono K, Iwata S, Moriya K, Tateda K. Molecular Characterization of IMP-1-Producing Enterobacter cloacae Complex Isolates in Tokyo. Antimicrob Agents Chemother. 2018 Feb 23;62(3):e02091-17.
    5. Ubukata K, Morozumi M, Sakuma M, Takata M, Mokuno E, Tajima T, Iwata S; AOM Surveillance Study Group. Etiology of Acute Otitis Media and Characterization of Pneumococcal Isolates After Introduction of 13-Valent Pneumococcal Conjugate Vaccine in Japanese Children. Pediatr Infect Dis J. 2018 Jun;37(6):598-604.
    6. Takesue Y, Kusachi S, Mikamo H, Sato J, Watanabe A, Kiyota H, Iwata S, Kaku M, Hanaki H, Sumiyama Y, Kitagawa Y, Nakajima K, Ueda T, Uchino M, Mizuguchi T, Ambo Y, Konosu M, Ishibashi K, Matsuda A, Hase K, Harihara Y, Okabayashi K, Seki S, Hara T, Matsui K, Matsuo Y, Kobayashi M, Kubo S, Uchiyama K, Shimizu J, Kawabata R, Ohge H, Akagi S, Oka M, Wakatsuki T, Suzuki K, Okamoto K, Yanagihara K. Antimicrobial susceptibility of common pathogens isolated from postoperative intra-abdominal infections in Japan. J Infect Chemother. 2018 May;24(5):330-340.
    7. Adachi Y, Ando M, Morozumi M, Ubukata K, Iwata S. Genotypic characterization of Haemophilus influenzae isolates from paediatric patients in Japan. J Med Microbiol. 2018 May;67(5):695-701.
    8. Ando M, Morozumi M, Adachi Y, Ubukata K, Iwata S. Multilocus Sequence Typing of Mycoplasma pneumoniae, Japan, 2002-2016. Emerg Infect Dis. 2018 Oct;24(10):1895-1901.
    9. Ubukata K, Takata M, Morozumi M, Chiba N, Wajima T, Hanada S, Shouji M, Sakuma M, Iwata S; Invasive Pneumococcal Diseases Surveillance Study Group. Effects of Pneumococcal Conjugate Vaccine on Genotypic Penicillin Resistance and Serotype Changes, Japan, 2010-2017. Emerg Infect Dis. 2018 Nov;24(11):2010-2020.
    10. Ubukata K, Takata T, Morozumi M, Chiba N, Wajima T, Hanada S, Shouji M, Sakuma M, Iwata S, and the Invasive Pneumococcal Diseases Surveillance Study Group. Impact of pneumococcal conjugate vaccine on genotypic penicillin resistance and serotype changes in isolates from invasive pneumococcal disease, Japan, 2010-2017. Emerg Infect Dis. 2018; 11 (in press)
    11. Ando M, Morozumi M, Adachi Y, Ubukata K, Iwata S. Multilocus sequence typing of macrolide-susceptible and -resistant Mycoplasma pneumoniae. Emerg Infect Dis. 2018; 10 (in press)
    12. Adachi Y, Ando M, Morozumi M, Ubukata K, Iwata S. Genotypic characterization of Haemophilus influenzae isolates from paediatric patients in Japan. J Med Microbiol. 2018. [Epub ahead of print]
    13. Ubukata K, Morozumi M, Sakuma M, Takata M, Mokuno E, Tajima T, Iwata S; and the AOM Surveillance Study Group. Etiology of acute otitis media and characterization of pneumococcal isolates after introduction of 13-valent pneumococcal conjugate vaccine in Japanese children. Pediatr Infect Dis J. 2018; 37:598-604.
    14. Shimokawa C, Senba M, Kobayashi S, Kikuchi M, Obi S, Olia A, Hamano S, Hisaeda H. Intestinal Inflammation-Mediated Clearance of Amebic Parasites Is Dependent on IFN-γ. J Immunol. 2018; 200:1101-1109.
    15. Imai K, Tarumoto N, Amo K, Takahashi M, Sakamoto N, Kosaka A, Kato Y, Mikita K, Sakai J, Murakami T, Suzuki Y, Maesaki S, Maeda T. Non-invasive diagnosis of cutaneous leishmaniasis by the direct boil loop-mediated isothermal amplification method and MinION™ nanopore sequencing. Parasitol Int. 2018; 67(1): 34-7.

  1. Okamori S, Asakura T, Nishimura T, Tamizu E, Ishii M, Yoshida M, Fukano H, Hayashi Y, Fujita M, Hoshino Y, Betsuyaku T, Hasegawa N. Natural history of Mycobacterium fortuitum pulmonary infection presenting with migratory infiltrates: a case report with microbiological analysis. BMC Infect Dis. 2018. Jan 2.18(1).1 (IF: 2.620, CI: -)
  2. Kohashi S, Toyama T, Hashimoto N, Sakurai M, Kato J, Kikuchi T, Koda Y, Sugita K, Hasegawa N, Yarita K, Kamei K, Okamoto S, Mori T. Sinusitis caused by Exserohilum rostratum after cord blood transplantation for myelodysplastic syndrome: A case report and literature review. Transpl Infect Dis. 2018. Feb 20. 20(1)
  3. Yagi K, Morimoto K, Ishii M, Namkoong H, Okamori S, Asakura T, Suzuki S, Asami T, Uwamino Y, Funatsu Y, Fujiwara H, Kamata H, Nishimura T, Betsuyaku T, Kurashima A, Hasegawa N. Clinical characteristics of pulmonary Mycobacterium lentiflavum disease in adult patients. Int J Infect Dis.2018 Feb. 67:65-69。
  4. Aasami T, Ishii M, Namkoong H, Yagi K, Tasaka S, Asakura T, Suzuki S, Kamo T, Okamori S, Kamata H, Zhang H, Hegab A, Hasegawa N, Betsuyaku T. Anti-inflammatory roles of mesenchymal stromal cells during acute Streptococcus pneumoniae pulmonary infection in mice. Cytotherapy. 2018 Mar. 20(3): 302-313.
  5. ★★★Namkoong H, Ishii M, Fujii H, Yagi K, Asami T, Asakura T, Suzuki S, Hegab AE, Kamata H, Tasaka S, Atarashi K, Nakamoto N, Iwata S, Honda K, Kanai T, Hasegawa N, Koyasu S, Betsuyaku T. Clarithromycin expands CD11b+Gr-1+ cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia. PLoS Pathog. 2018 Apr 5. 14(4): e1006955.
  6. Suzuki S, Asakura T, Namkoong H, Okamori S, Yagi K, Kamata H, Uwamino Y, Funatsu Y, Nakano Y, Nishimura T, Ishii M, Ebihara T, Betsuyaku T, Hasegawa N. Aspergillus precipitating antibody in patients with Mycobacterium avium complex lung disease: A cross-sectional study. Respir Med. 2018 May.138:1-6.
  7. Asakura T, Ishii M Ishii K, Suzuki S, Namkoong H, Okamori S, Kamata H, Yagi K, Funatsu Y, Betsuyaku T, Hasegawa N. Health-related QOL of elderly patients with pulmonary M.avium complex disease in a university hospital. Int J Tuberc Lung Dis 2018 Jun 1. 22(6):695-703.
  8. Yamazaki R, Kikuchi T, Kato J, Sakurai M, KodaY, Hashida R, Yamane Y, Abe R, Hasegawa N, Okamoto S, Mori T. Recurrent bacterial pneumonia due to immunoglobulin G2 subclass deficiency after allogeneic hematopoietic stem cell transplantation: Efficasy of immunoglobulin replacement. Transpl Infect Dis. 2018 Jun. 20(3):e12863.
  9. Matsuda S, Suzuki S, Morimoto K, Aono A, Nishio K, Asakura T, Sasaki Y Namkoong H, Nishimura T, Ogata H, Hasegawa N. Kusrashima A, Ishii M, Tatsumi K, Mitarai S, Goto H. Mycobacterium triplex pulmonary disease with acquired macrolide resistance in immunocompetent patients. Clin Microbiol Infect 2018 Jun. 24(6):671-672.
  10. Yagi K, Asakura T, Namkoong H, Suzuki S, Asami T, Okamori S, Kusumoto T, Funatsu Y, Kamata H, Nishimura T, Ishii M, Betsuyaku T, Hasegawa N. Association between six-minute walk test parameters and the health-related quality of life in patients with pulmonary Mycobacterium avium complex disease. BMC Pulm Med. 2018 Jul 13. 18(1):114.
  11. Asakura T, Yamada Y, Ishii M, Ebisudani T, Ueda S, Betsuyaku T, Hasegawa N. Perfusion defect-concordant progression of unilateral refractory pulmonary MAC disease. Am J Respir Crit Care Med. 2018 Sep 15.198 (6): 803-804.
  12. Namkoong H, Asakura T, Ishii M, Yoda S, Masaki K, Sakagami T, Iwasaki E, Yamagishi Y, Kanai T, Betsuyaku T, Hasegawa N. First report of hepatobilialy Mycobacterium avium infection developing obstructive jaundice in a patient with neutralizing anti-interferon-dgamma autoantibodies. New Microb New Infect 2018 Oct 19.27:4-6
  13. Nakamura T, Enoki Y, Uno S, Uwamino Y, Iketani O, Hasegawa N, Matsumoto K. Stability of benzylpenicillin potassium and ampicillin in an elastomeric infusion pump. J Infect Chemother 2018 Oct. 24(10):856-859.
  14. Uno S, Horiuchi Y, Uchida T, Yonaha A, Miyata T, Nagano E, Kodama T, Hasegawa N. A successful antimicrobial therapeutic strategy for the discitis caused by Aggregatibacter actinomycetemcomitans under unknown drug susceptibility: A case report. J Infect Chemother. 2018 Oct 24. (10):849-851.
  15. Kondo M, Sudo K, Sano T, Kawahata T, Itoda I, Iwamuro S, Yoshimura Y, Tachikawa N, Kojima Y, Mori H, Fujiwara H, Hasegawa N, Kato S. Comparative evaluation of the Geenius HIV 1/2 confirmatory assay and the HIV-1 and HIV-2 western blots in the Japanese population. PLoS One 2018 Oct 31. 13(10):e0198924.
  16. Nishimura T, Ota M, Mori M, Hasegawa N, Kawabe H, Kato S. Estimating Latent Tuberculosis Infection Using Interferon-γ Release Assay, Japan. Emerg Infect Dis . 2018 Nov. 24(11): 2111-2113.
  17. ★★★Kubota H, Uwamino Y, Matsui M, Sekizuka T, Suzuki Y, Okuno R, Uchitani Y, Ariyoshi T, Aoki W, Suzuki S, Kuroda M, Shinkai T, Yokoyama K, Sadamasu K, Funakoshi T, Murata M, Hasegawa N, Iwata S. FRI-4 carbapenemase-producing Enterobacter cloacae complex isolated in Tokyo, Japan. J Antimicrob Chemother. 2018 Nov 1. 73(11) 2969-2972.
  18. Nishimura T, Ota M, Mori M, Fujiwara H, Takano Y, Kato S, Kawabe H, Hasegawa N. Risk of tuberculosis infection among health care workers and nursing students in Japan. J Infect Chemother 2018 Nov :24(11):921-924.
  19. Asakura T, Ishii M, Namkoong H, Suzuki S, Kagawa S, Yagi K, Komiya T, Hashimoto T, Okamori S, Kamata H, Tasaka S, Kihara A, Hegab AE, Hasegawa N, Betsuyaku T. Sphingosine 1-phosphate receptor modulator ONO-4641 stimulates CD11b+Gr-1+ cell expansion and inhibits lymphocyte infiltration in the lungs to ameliorate murine pulmonary emphysema. Mucosal Immunol. 2018 Nov. 11(6):1606-1620.
  20. Asakura T, Yamada Y, Suzuki S, Namkoong H, Okamori S, Kusumoto T, Nijima Y, Ozaki A, Hashimoto M, Yagi K, Kamata H, Funatsu Y, Ishii M, Jinzaki M, Betsuyaku T, Hasegawa N. Quantitative assessment of erector spinae muscles in patients with Mycobacterium avium complex lung disease. Respir Med. 2018 Dec. 145: 66-72.
  21. Morimoto K, Nakagawa T, Asami T, Morino E, Fujiwara H, Hase I, Tsujimoto Y, Izumi K, Hayashi Y, Matsuda S, Murase Y, Yano R, Takasaki J, Betsuyaku T, Aono A, Goto H, Nishimura T, Sasaki Y, Hoshino Y, Kurashima A, Ato M, Ogawa K, Hasegawa N, Mitarai S. Clinico-microbiological analysis of 121 patients with pulmonary Mycobacteroides abscessus complex disease in Japan - An NTM-JRC study with RIT. Respir Med. 2018 Dec. 145:14-20.
  22. Griffith DE, Eagle G, Thomson R, Aksamit TR, Hasegawa N, Morimoto K, Addrizzo-Harris DJ, O’Donnell AE, Marras TK, Flume PA, Loebinger MR, Morgan L, Codecasa LR, Hill AT, Ruoss SJ, Yim JJ, Ringshausen FC, Field SK, Philley JV, Wallace RJ Jr, van Ingen J, Coulter C, Nezamis J, Winthrop KL, CONVERT Study Group. Amikacin liposome inhalation suspension for treatment-refractory lung disease caused by Mycobacterium avium complex (CONVERT): A Prospective, open-label, randomized study. Am J Respir Crit Care Med. 2018 Dec 15.198(12):1559-1569.
  23. Horiuchi K, Asakura T, Hasegawa N, Saito F. Recurrence of allergic bronchopulmonary aspergillosis after adjunctive surgery for aspergillosis after adjunctive surgery for aspergilloma:A case report with long-term follow-up. BMC Pulm Med. 2018 Dec 4. 18(1):185.
  24. ★★★Imai K, Tarumoto N, Amo K, Takahashi M, Sakamoto N, Kosaka A, Kato Y, Mikita K, Sakai J, Murakami T, Suzuki Y, Maesaki S, Maeda T. Non-invasive diagnosis of cutaneous leishmaniasis by the direct boil loop-mediated isothermal amplification method and MinION™ nanopore sequencing. Parasitol Int. 2018 Feb;67(1):34-37.
  25. ★★★Aoki K, Harada S, Yahara K, Ishii Y, Motooka D, Nakamura S, Akeda Y, Iida T, Tomono K, Iwata S, Moriya K, Tateda K. Molecular Characterization of IMP-1-Producing Enterobacter cloacae Complex Isolates in Tokyo. Antimicrob Agents Chemother. 2018 Feb 23;62(3):e02091-17.
  26. ★★★Ubukata K, Morozumi M, Sakuma M, Takata M, Mokuno E, Tajima T, Iwata S; AOM Surveillance Study Group. Etiology of Acute Otitis Media and Characterization of Pneumococcal Isolates After Introduction of 13-Valent Pneumococcal Conjugate Vaccine in Japanese Children. Pediatr Infect Dis J. 2018 Jun;37(6):598-604.
  27. ★★★Takesue Y, Kusachi S, Mikamo H, Sato J, Watanabe A, Kiyota H, Iwata S, Kaku M, Hanaki H, Sumiyama Y, Kitagawa Y, Nakajima K, Ueda T, Uchino M, Mizuguchi T, Ambo Y, Konosu M, Ishibashi K, Matsuda A, Hase K, Harihara Y, Okabayashi K, Seki S, Hara T, Matsui K, Matsuo Y, Kobayashi M, Kubo S, Uchiyama K, Shimizu J, Kawabata R, Ohge H, Akagi S, Oka M, Wakatsuki T, Suzuki K, Okamoto K, Yanagihara K. Antimicrobial susceptibility of common pathogens isolated from postoperative intra-abdominal infections in Japan. J Infect Chemother. 2018 May;24(5):330-340.
  28. ★★★Adachi Y, Ando M, Morozumi M, Ubukata K, Iwata S. Genotypic characterization of Haemophilus influenzae isolates from paediatric patients in Japan. J Med Microbiol. 2018 May;67(5):695-701.
  29. ★★★Ando M, Morozumi M, Adachi Y, Ubukata K, Iwata S. Multilocus Sequence Typing of Mycoplasma pneumoniae, Japan, 2002-2016. Emerg Infect Dis. 2018 Oct;24(10):1895-1901.
  30. ★★★Ubukata K, Takata M, Morozumi M, Chiba N, Wajima T, Hanada S, Shouji M, Sakuma M, Iwata S; Invasive Pneumococcal Diseases Surveillance Study Group. Effects of Pneumococcal Conjugate Vaccine on Genotypic Penicillin Resistance and Serotype Changes, Japan, 2010-2017. Emerg Infect Dis. 2018 Nov;24(11):2010-2020.
  31. ★★★Ubukata K, Takata T, Morozumi M, Chiba N, Wajima T, Hanada S, Shouji M, Sakuma M, Iwata S, and the Invasive Pneumococcal Diseases Surveillance Study Group. Impact of pneumococcal conjugate vaccine on genotypic penicillin resistance and serotype changes in isolates from invasive pneumococcal disease, Japan, 2010-2017. Emerg Infect Dis. 2018; 11 (in press)
  32. ★★★Ando M, Morozumi M, Adachi Y, Ubukata K, Iwata S. Multilocus sequence typing of macrolide-susceptible and -resistant Mycoplasma pneumoniae. Emerg Infect Dis. 2018; 10 (in press)
  33. ★★★Adachi Y, Ando M, Morozumi M, Ubukata K, Iwata S. Genotypic characterization of Haemophilus influenzae isolates from paediatric patients in Japan. J Med Microbiol. 2018. [Epub ahead of print]
  34. ★★★Ubukata K, Morozumi M, Sakuma M, Takata M, Mokuno E, Tajima T, Iwata S; and the AOM Surveillance Study Group. Etiology of acute otitis media and characterization of pneumococcal isolates after introduction of 13-valent pneumococcal conjugate vaccine in Japanese children. Pediatr Infect Dis J. 2018; 37:598-604.
  35. ★★★Shimokawa C, Senba M, Kobayashi S, Kikuchi M, Obi S, Olia A, Hamano S, Hisaeda H. Intestinal Inflammation-Mediated Clearance of Amebic Parasites Is Dependent on IFN-γ. J Immunol. 2018; 200:1101-1109.
  36. ★★★Imai K, Tarumoto N, Amo K, Takahashi M, Sakamoto N, Kosaka A, Kato Y, Mikita K, Sakai J, Murakami T, Suzuki Y, Maesaki S, Maeda T. Non-invasive diagnosis of cutaneous leishmaniasis by the direct boil loop-mediated isothermal amplification method and MinION™ nanopore sequencing. Parasitol Int. 2018; 67(1): 34-7.

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Research and Achievements