Research Themes

4.Research on HIV Strains and HIV Patients

Research Overview

Human Immunodeficiency Virus (HIV) Infection
Advances in antiviral therapy have made it possible for people living with HIV to achieve a life expectancy equivalent to those without the infection. Furthermore, it has been shown that when the viral load is controlled, the risk of transmitting the virus to others is eliminated. However, new cases of HIV infection continue to be reported in Japan, and various measures are still needed to bring the epidemic to an end. Additionally, with the aging of patients, non-AIDS-related complications have become a significant issue.

At our institution, we conduct clinical research on the relationship between HIV drug resistance and treatment, complications, and immune responses in HIV-infected individuals. We also participate in the Japanese Drug Resistance HIV-1 Surveillance Network, engaging in multi-institutional collaborative research.

Key Research Achievements

  1. Kawakami N, Namkoong H, Shimoda M, Kotani H, Fujiwara H, Hasegawa N. Hidden disseminated extracutaneous AIDS-related Kaposi sarcoma. IDCases. 2020 Feb 10;19:e00716. doi: 10.1016/j.idcr.2020.e00716. eCollection 2020.
  2. Kawakami N, Namkoong H, Masaki K, Kurebayashi Y, Shimoda M, Kotani H, Fujiwara H, Hasegawa N. IL-6 and G-CSF production resulting from lung cancer in an HIV patient. IDCases. 2020 Jan 9;19:e00693. doi: 10.1016/j.idcr.2020.e00693. eCollection 2020.
  3. Asakura T, Namkoong H, Sakagami T, Hasegawa N, Ohkusu K, Nakamura A. Disseminated Mycobacterium genavense Infection in Patient with Adult-Onset Immunodeficiency. Emerg Infect Dis. 2017 Jul;23(7):1208-1210. doi: 10.3201/eid2307.161677.
  4. Namkoong H, Fujiwara H, Ishii M, Yagi K, Haraguchi M, Matsusaka M, Suzuki S, Asakura T, Asami T, Saito F, Fukunaga K, Tasaka S, Betsuyaku T, Hasegawa N. Immune reconstitution inflammatory syndrome due to Mycobacterium avium complex successfully followed up using 18 F-fluorodeoxyglucose positron emission tomography-computed tomography in a patient with human immunodeficiency virus infection: A case report. BMC Med Imaging. 2015 Jul 18;15:24. doi: 10.1186/s12880-015-0063-2.

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